Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of human mesenchymal stem cells transformed with lentiviral vectors of TERT, E6, SV40 and RAS

ABSTRACT: Mesenchymal Stem Cells are transformed by step-wise stable transfection with lentiviral vectors of TERT, E6, E7, SV40, and Ras.

ORGANISM(S): Homo sapiens

SUBMITTER: Stephen Henderson

PROVIDER: E-MEXP-563 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production.

Funes Juan M JM Quintero Marisol M Henderson Stephen S Martinez Dolores D Qureshi Uzma U Westwood Claire C Clements Mark O MO Bourboulia Dimitra D Pedley R Barbara RB Moncada Salvador S Boshoff Chris C

Proceedings of the National Academy of Sciences of the United States of America 20070323 15

An increased dependency on glycolysis for ATP production is considered to be a hallmark of tumor cells. Whether this increase in glycolytic activity is due mainly to inherent metabolic alterations or to the hypoxic microenvironment remains controversial. Here we have transformed human adult mesenchymal stem cells (MSC) using genetic alterations as described for differentiated cells. Our data suggest that MSC require disruption of the same pathways as have been shown for differentiated cells to c ...[more]

PMID: 17384149

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Dataset Information

Transcription profiling of human mesenchymal stem cells transformed with lentiviral vectors of TERT, E6, SV40 and RAS

Publications

Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production.

Similar Datasets

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