Transcription profiling of human PC3 prostate cells transfected with FGF-8b vs control vector

ABSTRACT: The aim of this study was to identify molecular targets for FGF-8 associated with prostate cancer progression in PC3 prostate cancer cells. PC3 prostate cancer cells were stably transfected with FGF-8b or control vector (mock). Expression of FGF-8 in PC3 cells increased cell growth and MMP-production in vitro. Microarray analyses revealed 169 significantly altered genes (>2.0-fold), some of the which were known to be associated with cancer growth and may represent novel markers of FGF-8 function. Upregulated genes included those involved in angiogenesis or cell growth (DDAH2, CRIP1 and SHC). Genes associated with differentiation or cell death were downregulated (VDR, CYCS). This study demonstrates associated patterns of gene expressions for FGF-8 in prostate cancer. This analysis may help

INSTRUMENT(S): G2565AA DNA microarray scanner [Agilent]

ORGANISM(S): Homo sapiens

SUBMITTER: Maija Valta 

PROVIDER: E-MEXP-581 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress