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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human normal progenitor cells mutated for RUNX1-RUNX1 during myeloid and erythroid development to identify genes disregulated by RUNX1-RUNX1

ABSTRACT: In order to identify genes dysregulated by the aberrant transcriptional activity of RUNX1-RUNX1T1, we used microarrays to determine the effect of this mutation on gene expression during myeloid and erythroid development of normal human progenitor cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Alex Tonks

PROVIDER: E-MEXP-583 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia.

Tonks A A Pearn L L Musson M M Gilkes A A Mills K I KI Burnett A K AK Darley R L RL

Leukemia 20070927 12

The t(8;21)(q22;q22) occurs frequently in acute myelogenous leukaemia and gives rise to the transcription factor fusion protein, RUNX1-RUNX1T1 (also known as AML1-ETO). To identify the genes dysregulated by the aberrant transcriptional activity of RUNX1-RUNX1T1, we used microarrays to determine the effect of this mutation on gene expression in human progenitor cells and during subsequent development. Gene signatures of these developmental subsets were very dissimilar indicating that effects of R ...[more]

PMID: 17898786

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