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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse primary capillary PlGF-/- endothelial cells treated with 100 ng/ml PlGF for 6 hours

ABSTRACT: PlGF expression profile in primary capillary PlGF-/- endothelial cells treated with 100 ng/ml PlGF during 6 hours.

ORGANISM(S): Mus musculus

SUBMITTER: Stephane Plaisance

PROVIDER: E-MEXP-6 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1.

Autiero Monica M Waltenberger Johannes J Communi Didier D Kranz Andrea A Moons Lieve L Lambrechts Diether D Kroll Jens J Plaisance Stephane S De Mol Maria M Bono Françoise F Kliche Stefanie S Fellbrich Guido G Ballmer-Hofer Kurt K Maglione Domenico D Mayr-Beyrle Ulrike U Dewerchin Mieke M Dombrowski Saskia S Stanimirovic Danica D Van Hummelen Paul P Dehio Christoph C Hicklin Daniel J DJ Persico Graziella G Herbert Jean-Marc JM Communi David D Shibuya Masabumi M Collen Désiré D Conway Edward M EM Carmeliet Peter P

Nature medicine 20030701 7

Therapeutic angiogenesis is likely to require the administration of factors that complement each other. Activation of the receptor tyrosine kinase (RTK) Flk1 by vascular endothelial growth factor (VEGF) is crucial, but molecular interactions of other factors with VEGF and Flk1 have been studied to a limited extent. Here we report that placental growth factor (PGF, also known as PlGF) regulates inter- and intramolecular cross talk between the VEGF RTKs Flt1 and Flk1. Activation of Flt1 by PGF res ...[more]

PMID: 12796773

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