Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of GATA-6 overexpression in mouse P19CL6 cells to identify targets of GATA-6 transcriptional regulation at early stages of cardiogenesis

ABSTRACT: effect of overexpression of GATA-6 in P19 CL6 induced cells

ORGANISM(S): Mus musculus

SUBMITTER: Matthew Arno

PROVIDER: E-MEXP-628 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Wnt2 is a direct downstream target of GATA6 during early cardiogenesis.

Alexandrovich Alexander A Arno Matthew M Patient Roger K RK Shah Ajay M AM Pizzey John A JA Brewer Alison C AC

Mechanisms of development 20060418 4

The GATA4, 5 and 6 subfamily of transcription factors are potent transactivators of transcription expressed within the precardiac mesoderm. However, little is known of the immediate downstream targets of GATA-factor regulation during the earliest stages of cardiogenesis. Using the P19-CL6 embryonal carcinoma (EC) cell line as an in vitro model of cardiogenesis, we show that GATA6 is the most abundantly expressed of the GATA factors in presumptive cardiac cells. Consequently, we performed a micro ...[more]

PMID: 16621466

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Dataset Information

Transcription profiling of GATA-6 overexpression in mouse P19CL6 cells to identify targets of GATA-6 transcriptional regulation at early stages of cardiogenesis

Publications

Wnt2 is a direct downstream target of GATA6 during early cardiogenesis.

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