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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of S. cerevisiae strains with controlled expression of hmo1 and Ifh1

ABSTRACT: Effect of hmo1 on yeast transcriptional response, as compared to Ifh1

INSTRUMENT(S): GenePix 4000A [Axon Instruments]

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Olivier GADAL

PROVIDER: E-MEXP-651 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription.

Berger Axel B AB Decourty Laurence L Badis Gwenaël G Nehrbass Ulf U Jacquier Alain A Gadal Olivier O

Molecular and cellular biology 20070917 22

Ribosome biogenesis requires equimolar amounts of four rRNAs and all 79 ribosomal proteins (RP). Coordinated regulation of rRNA and RP synthesis by eukaryotic RNA polymerases (Pol) I, III, and II is a key requirement for growth control. Using a novel global genetic approach, we showed that the absence of Hmo1 becomes lethal when combined with mutations of components of either the RNA Pol II or Pol I transcription machineries, of specific RP, or of the TOR pathway. Hmo1 directly interacts with bo ...[more]

PMID: 17875934

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