Transcription profiling of C. elegans after infection with Microbacterium nematophilum
Ontology highlight
ABSTRACT:
The interaction between the nematode Caenorhabditis elegans and a Gram-positive bacterial pathogen, Microbacterium nematophilum, provides a model for an innate immune response in nematodes. This pathogen adheres to the rectal and post-anal cuticle of the worm, causing slowed growth, constipation, and a defensive swelling response of rectal hypodermal cells. To explore the genomic responses that the worm activates after pathogenic attack we used microarray analysis of transcriptional changes induced after 6 hr infection, comparing virulent with avirulent infection.
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Delia O'Rourke
PROVIDER: E-MEXP-696 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum.
O'Rourke Delia D Baban Dilair D Demidova Maria M Mott Richard R Hodgkin Jonathan J
Genome research 20060629 8
The interaction between the nematode Caenorhabditis elegans and a Gram-positive bacterial pathogen, Microbacterium nematophilum, provides a model for an innate immune response in nematodes. This pathogen adheres to the rectal and post-anal cuticle of the worm, causing slowed growth, constipation, and a defensive swelling response of rectal hypodermal cells. To explore the genomic responses that the worm activates after pathogenic attack we used microarray analysis of transcriptional changes indu ...[more]
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