Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse TGF-a induction in saccular phase and alveolar phase lung morphogenesis in mice

ABSTRACT: Effect of TGFa induction on saccular phase or alveolar phase lung morphogenesis in mice.

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Mus musculus

SUBMITTER: Machiko Ikegami 

PROVIDER: E-MEXP-698 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.

Kramer Elizabeth L EL   Deutsch Gail H GH   Sartor Maureen A MA   Hardie William D WD   Ikegami Machiko M   Korfhagen Thomas R TR   Le Cras Timothy D TD  

American journal of physiology. Lung cellular and molecular physiology 20070427 2

Transforming growth factor-alpha (TGF-alpha) and its receptor, the epithelial growth factor receptor (EGFR), have been associated with lung remodeling in premature infants with bronchopulmonary dysplasia (BPD). The goal of this study was to target TGF-alpha overexpression to the saccular phase of lung morphogenesis and determine early alterations in gene expression. Conditional lung-specific TGF-alpha bitransgenic mice and single-transgene control mice were generated. TGF-alpha overexpression wa  ...[more]

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