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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of hippocampus from wild type and CIC-6 knock-out mice

ABSTRACT: 3 pairs of wt and ClC-6 knockout mice, RNA from p14 hippocampus

ORGANISM(S): Mus musculus

SUBMITTER: Jens Fuhrmann

PROVIDER: E-MEXP-731 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6.

Poët Mallorie M Kornak Uwe U Schweizer Michaela M Zdebik Anselm A AA Scheel Olaf O Hoelter Sabine S Wurst Wolfgang W Schmitt Anja A Fuhrmann Jens C JC Planells-Cases Rosa R Mole Sara E SE Hübner Christian A CA Jentsch Thomas J TJ

Proceedings of the National Academy of Sciences of the United States of America 20060901 37

Mammalian CLC proteins function as Cl(-) channels or as electrogenic Cl(-)/H(+) exchangers and are present in the plasma membrane and intracellular vesicles. We now show that the ClC-6 protein is almost exclusively expressed in neurons of the central and peripheral nervous systems, with a particularly high expression in dorsal root ganglia. ClC-6 colocalized with markers for late endosomes in neuronal cell bodies. The disruption of ClC-6 in mice reduced their pain sensitivity and caused moderate ...[more]

PMID: 16950870

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