Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

12 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of wild type and Ahr(-/-) mouse embryo fibroblast cells

ABSTRACT: Wildtype vs. Ahr(-/-) mouse embryo fibroblast cells were compared in a flipped-dye design

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Mus musculus

SUBMITTER: Scott Wesselkamper

PROVIDER: E-MEXP-787 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments.

Sartor Maureen A MA Tomlinson Craig R CR Wesselkamper Scott C SC Sivaganesan Siva S Leikauf George D GD Medvedovic Mario M

BMC bioinformatics 20061219

<h4>Background</h4>The small sample sizes often used for microarray experiments result in poor estimates of variance if each gene is considered independently. Yet accurately estimating variability of gene expression measurements in microarray experiments is essential for correctly identifying differentially expressed genes. Several recently developed methods for testing differential expression of genes utilize hierarchical Bayesian models to "pool" information from multiple genes. We have develo ...[more]

PMID: 17177995

Similar Datasets

Transcription profiling of C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD

Project description:Comparison of lung function in C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD.

2007-03-08 | E-MEXP-855 | biostudies-arrayexpress

Transcription profiling of mouse T cell sub-populations isolated from pulmonary tissue after mice were exposured to filtered air of acrolein for one week

Project description:Mice were exposed to filtered air or acrolein for 1 week. T cell subpopulations were isolated from the pulmonary tissue by cell sorting.

2008-11-15 | E-MEXP-1354 | biostudies-arrayexpress

Transcription profiling of dox-inducible, bitransgenic Ccsp-rtta x Teto-fgf7 mice lungs to 1 and 3 days of doxycycline treatment

Project description:Response of dox-inducible, bitransgenic Ccsp-rtta x Teto-fgf7 mice to 1 and 3 days of doxycycline treatment

2022-11-22 | E-MEXP-644 | biostudies-arrayexpress

Transcription profiling of mouse TGF-a induction in saccular phase and alveolar phase lung morphogenesis in mice

Project description:Effect of TGFa induction on saccular phase or alveolar phase lung morphogenesis in mice.

2022-11-21 | E-MEXP-698 | biostudies-arrayexpress

Transcription profiling of mouse activin treated MEKK1 wild type and KO keratinocytes

Project description:MEKK1 wildtype and knockout keratinocytes were compared both with and without activin (10 ng/ml) treatment for 12 hours, and control vs activin treated cells were compared both for wildtype and knockout. This was performed in a square design.

2007-11-20 | E-MEXP-355 | biostudies-arrayexpress

Transcription profiling of mouse fibroblasts expressing the 57Bl/6 Ah-receptor vs. Ahr-/- fibroblasts synchronized at G0/G1, S-phase, and in exponential growth

Project description:Role of the Ah-receptor in cell cycle regulation. Mouse fibroblasts expressing the Ah-receptor of C57Bl/6 mice under the regulation of the Tet*Off system were compared to Ahr-/- fibroblasts synchronized at G0/G1, S-phase, or in exponential growth.

2007-08-05 | E-MEXP-996 | biostudies-arrayexpress

Transcription profiling of lung from wild type and Mt1(-/-)Mt2(-/-) double knock-out mice after nickel aerosol exposure for 3, 8, 24, 48, and 72 hrs

Project description:Wildtype and Mt1(-/-)Mt2(-/-) double knockout 129S1/SvImJ strain mouse lungs were compared in their response to nickel aerosol exposure at 3, 8, 24, 48, and 72 hrs.

2006-08-02 | E-MEXP-816 | biostudies-arrayexpress

Transcription profiling of mouse placenta to determine the relative effects of maternal and fetal genotype on the placental transcriptome at E18.5

Project description:The placenta plays a crucial role in the normal growth and development in mammals by serving as an interface for nutrients, respiratory gases and physiological signals between the mother and fetus. Here we use a novel embryo transfer system in mice to identify the major physiological pathways in the placenta that are principally influenced by altered maternal environment. Embryos of identical genotype were transferred at the one cell stage into surrogate mothers either of the same strain or from a different strain. We analyzed the relative effects of maternal and fetal genotype on fetal weight, placental weight and the placental transcriptome at E18.5. The results show that maternal genotype overrides fetal genotype as the principal regulator of fetal weight (p<0.0001). Microarray analysis of the transcriptome in placentas revealed that a small fraction (0.25%) of placental genes are specifically regulated by maternal genotype (p<0.05, FDR<0.10). Pathway analysis of these genes using the programs Gene Ontology and MetaCore from GeneGO inc. revealed highest statistical significance in signaling pathways that regulate cell growth and lipid metabolism. These results provide a mechanistic understanding of important molecular pathways involved in maternal regulation of fetal growth and development.

2010-08-06 | E-MEXP-2479 | biostudies-arrayexpress

Transcription profiling of lung from mice with doxycycline-induced TGFa-over-expression for 6 up to weeks, and up to 6 weeks of recovery to study TGFa-induced pulmonary fibrosis

Project description:Time series response to Doxycycline-induced TGFa-overexpression for 6 up to weeks, and up to 6 weeks of recovery.

2007-05-23 | E-MEXP-966 | biostudies-arrayexpress

Transcription profiling of Puga- tBHQ and arsenic treated GCLM-WT and KO mice

Project description:Evaluate the protective effect of prior tBHQ treatment from arsenic damage at two dosage levels of arsenic (2 and 20 uM), and compare to the effect of tBHQ or arsenic treatment given alone.

2005-12-08 | E-MEXP-371 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data