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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Comparative genomic hybridization of benign epithelial and prostate cancer cell lines derived from the same patient

ABSTRACT: Copy number alterations in a matched pair of benign epithelial and prostate cancer cell lines derived from the same patient were assessed using array-based comparative genomic hybridisation (aCGH). the cancer cell line showed a gain of chromosome 7, deletion of chromosome 8, gains and losses in chromosome 11, loss of 18p and gain of 20q. Deletions on chromosome 8 were confirmed with microsatellite markers.

INSTRUMENT(S): Axon Instruments GenePix 4000B scanner

ORGANISM(S): Homo sapiens

DISEASE(S): prostate cancer

SUBMITTER: Magali Williamson

PROVIDER: E-MEXP-803 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide screening for genetic changes in a matched pair of benign and prostate cancer cell lines using array CGH.

Brookman-Amissah N N Duchesnes C C Williamson M P MP Wang Q Q Ahmed A A Feneley M R MR Mackay A A Freeman A A Fenwick K K Iravani M M Weber B B Ashworth A A Masters J R JR

Prostate cancer and prostatic diseases 20050101 4

Copy number alterations in a matched pair of benign epithelial and prostate cancer cell lines derived from the same patient were assessed using array-based comparative genomic hybridisation (aCGH). The cancer cell line showed a gain of chromosome 7, deletion of chromosome 8, gains (including high level) and losses on chromosome 11, loss of 18p and gain of 20q. Deletions on chromosome 8 were confirmed with microsatellite markers. The aCGH results were compared to gene expression data obtained usi ...[more]

PMID: 16130014

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