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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling time series toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration

ABSTRACT: Effect of vehicle vs non-toxic and toxic paracetamol (151mg/kg and 529mg/kg) doses on the gene expression profile at 1, 4 and 24h in murine liver.

ORGANISM(S): Mus musculus

SUBMITTER: Gilles Hanton

PROVIDER: E-MEXP-82 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Time course toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration.

Williams D P DP Garcia-Allan C C Hanton G G LeNet J L JL Provost J P JP Brain P P Walsh R R Johnston G I GI Smith D A DA Park B K BK

Chemical research in toxicology 20041201 12

Adverse drug reactions are a major clinical problem. Drug-induced hepatotoxicity constitutes a large percentage of these reactions. A thorough understanding of the genetic events, specifically, the early "decision-making" processes underlying biological changes caused by drugs and metabolites, is required. To assist in the understanding of these events, we have employed the model hepatotoxin, paracetamol (APAP), and GeneChip technology to investigate global genetic events seen after nontoxic and ...[more]

PMID: 15606129

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