Transcription profiling of Paracoccidioides brasiliensis yeast cells grown inside murine macrophages and in vitro
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Cyclone Storage Phosphor System
ORGANISM(S): Paracoccidioides brasiliensis
SUBMITTER: Maria Jose de Carvalho
PROVIDER: E-MEXP-823 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Early transcriptional response of Paracoccidioides brasiliensis upon internalization by murine macrophages.
Tavares Aldo Henrique F P AH Silva Simoneide S SS Dantas Alessandra A Campos Elida G EG Andrade Rosângela V RV Maranhão Andréa Q AQ Brígido Marcelo M MM Passos-Silva Danielle G DG Fachin Ana L AL Teixeira Santuza M R SM Passos Geraldo A S GA Soares Célia M A CM Bocca Anamélia L AL Carvalho Maria José A MJ Silva-Pereira Ildinete I Felipe Maria Sueli S MS
Microbes and infection 20070220 5
Paracoccidioides brasiliensis, a thermal dimorphic fungus, is the etiologic agent of the most common systemic mycosis in Latin America, paracoccidioidomycosis. The yeast form of P. brasiliensis acts as a facultative intracellular pathogen being able to survive and replicate within the phagosome of nonactivated murine and human macrophages. This ability has been proposed to be crucial to the development of disease. Thus, P. brasiliensis may have evolved mechanisms that counteract the constraints ...[more]
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