Transcription profiling of brain samples from human control and schizophrenia patients who were treated with either typical, atypical or no antipsychotic medication

ABSTRACT: Multiple studies have shown that brain gene expression is disturbed in subjects suffering from schizophrenia. However, disentangling disease effects from alterations caused by neuroleptics is a challenging task.
To address the issues of disease heterogeneity and the effect of antipsychotic medication, we use a large collection of 110 brain autopsy samples, subdivided according to the type of antipsychotic medication received. We use global and high-resolution mRNA quantification techniques to analyse gene expression in brain tissues. We also analyse transcription in-vitro, in cell lines before and after treatment with cytokines.
Results. We show that inflammation-related genes are up regulated in all groups of patients, including those not treated at the time of death. In particul

INSTRUMENT(S): GenePix Personal 4100A [Axon Instruments]

ORGANISM(S): Homo sapiens

DISEASE(S): reference

SUBMITTER: Johan Kreuger 

PROVIDER: E-MEXP-857 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress