Transcription profiling time series of mouse hippocampal neuronal cultures during development
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Paul Charlesworth
PROVIDER: E-MEXP-878 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Network activity-independent coordinated gene expression program for synapse assembly.
Valor Luis M LM Charlesworth Paul P Humphreys Lawrence L Anderson Chris N G CN Grant Seth G N SG
Proceedings of the National Academy of Sciences of the United States of America 20070305 11
Global biological datasets generated by genomics, transcriptomics, and proteomics provide new approaches to understanding the relationship between the genome and the synapse. Combined transcriptome analysis and multielectrode recordings of neuronal network activity were used in mouse embryonic primary neuronal cultures to examine synapse formation and activity-dependent gene regulation. Evidence for a coordinated gene expression program for assembly of synapses was observed in the expression of ...[more]
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