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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human osteoblasts differentiated from human mesenchymal stem cells and treated with three bioactive peptides

ABSTRACT: Effects of bioactive peptides IPP(Ile-Pro-Pro), VPP (Val-Pro-Pro), and LKP(Leu-Lys-Pro) on gene expression of osteoblast differentiated from human mesenchymal stem cells. Experimental design types: compound treatment and augmented reference design.

INSTRUMENT(S): ScanArray [PerkinElmer]

ORGANISM(S): Homo sapiens

SUBMITTER: Minna Pekkinen

PROVIDER: E-MEXP-885 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Effects of bioactive peptides isoleucine-proline-proline (IPP), valine-proline-proline (VPP) and leucine-lysine-proline (LKP) on gene expression of osteoblasts differentiated from human mesenchymal stem cells.

Huttunen Minna M MM Pekkinen Minna M Ahlström Mikael E B ME Lamberg-Allardt Christel J E CJ

The British journal of nutrition 20070430 4

Food-derived bioactive peptides are reported to express a variety of functions in vivo. We studied the in vitro effect of three bioactive tripeptides, isoleucine-proline-proline (IPP), valine-proline-proline (VPP) and leucine-lysine-proline (LKP), on osteoblast proliferation and gene expression. We used UMR-106 osteosarcoma cells, human marrow-derived mesenchymal stem cells (hMSC) and osteoblasts differentiated from hMSC. Treatment with 50 mum-IPP increased UMR-106 cell and hMSC proliferation. T ...[more]

PMID: 17466096

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