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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mammary glands from wild type and Akt1 knock out lactating mice at day 9 after parturition

ABSTRACT: A comparison of gene expression in the mammary gland of lactating mice at day 9 after parturition between Akt -/- and wildtype individuals.

ORGANISM(S): Mus musculus

SUBMITTER: Douglas Stairs

PROVIDER: E-MEXP-891 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.

Boxer Robert B RB Stairs Douglas B DB Dugan Katherine D KD Notarfrancesco Kathleen L KL Portocarrero Carla P CP Keister Blaine A BA Belka George K GK Cho Han H Rathmell Jeffrey C JC Thompson Craig B CB Birnbaum Morris J MJ Chodosh Lewis A LA

Cell metabolism 20061201 6

The metabolic demands and synthetic capacity of the lactating mammary gland exceed that of any other tissue, thereby providing a useful paradigm for understanding the developmental regulation of cellular metabolism. By evaluating mice bearing targeted deletions in Akt1 or Akt2, we demonstrate that Akt1 is specifically required for lactating mice to synthesize sufficient quantities of milk to support their offspring. Whereas cellular proliferation, differentiation, and apoptosis are unaffected, l ...[more]

PMID: 17141631

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