Dataset Information
Transcription profiling of hepatocytes from mice that are hyperglycaemic, obese and insulin resistant as a result of being fed a high fat diet
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Dominique Gauguier
PROVIDER: E-MEXP-893 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice.
Diabetologia 20070706 9
<h4>Aims/hypothesis</h4>Complex changes in gene expression are associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD) promoted by feeding a high-fat diet (HFD). We used functional genomic technologies to document molecular mechanisms associated with diet-induced NAFLD.<h4>Materials and methods</h4>Male 129S6 mice were fed a diet containing 40% fat (high-fat diet, HFD) for 15 weeks. Glucose tolerance, in vivo insulin secretion, plasma lipid profile and adiposity were det ...[more]
