Transcription profiling of hippocampi from scopolamine treated adult rats following stimulation in a spatial memory task
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Rémi Quirion
PROVIDER: E-MEXP-920 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia.
Brouillette Jonathan J Young Deborah D During Matthew J MJ Quirion Rémi R
Journal of neurochemistry 20070601 6
Scopolamine-treated rats are commonly used as a psychopharmacological model of memory dysfunction and have been extensively studied to establish the effectiveness of acetylcholinesterase inhibitors in the treatment of Alzheimer's disease. Scopolamine is a muscarinic acetylcholine receptor antagonist that induces memory deficits in young subjects similar to those occurring during aging. The amnesic effect of scopolamine is well established but the molecular and cellular mechanisms that sustain it ...[more]
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