Transcription profiling of human fibroblasts and keratinocytes after 125IUdR-elicited radiation treatment
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Scanning hardware
ORGANISM(S): Homo sapiens
SUBMITTER: Mykyta Sokolov
PROVIDER: E-MEXP-929 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide gene expression changes in normal human fibroblasts in response to low-LET gamma-radiation and high-LET-like 125IUdR exposures.
Sokolov M M Panyutin I G IG Neumann R R
Radiation protection dosimetry 20061204 1-4
Functional genomics studies were carried out to characterize the transcriptional response of normal human fibroblasts to ionizing radiation (IR) of different types. To this end, lung fibroblast IMR-90 cultures were exposed either to external beam gamma-radiation or to internal irradiation from decay of (125)I-labeled deoxyuridine ((125)IUdR) incorporated into the cellular DNA. A relatively small dose of 1 Gy of gamma-radiation was delivered to cell cultures either at a high dose-rate (HDR, 1 Gy, ...[more]
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