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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse embryonic stem cells, inner cell mass, epiblast and pluripotent cells derived from mouse epiblast under defined culture conditions

ABSTRACT: Transcriptional comparison of mouse embryonic stem cells, inner cell mass, epiblast and pluripotent cells derived from mouse epiblast under defined culture conditions.

ORGANISM(S): Mus musculus

SUBMITTER: Matthew Trotter

PROVIDER: E-MEXP-955 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Derivation of pluripotent epiblast stem cells from mammalian embryos.

Brons I Gabrielle M IG Smithers Lucy E LE Trotter Matthew W B MW Rugg-Gunn Peter P Sun Bowen B Chuva de Sousa Lopes Susana M SM Howlett Sarah K SK Clarkson Amanda A Ahrlund-Richter Lars L Pedersen Roger A RA Vallier Ludovic L

Nature 20070627 7150

Although the first mouse embryonic stem (ES) cell lines were derived 25 years ago using feeder-layer-based blastocyst cultures, subsequent efforts to extend the approach to other mammals, including both laboratory and domestic species, have been relatively unsuccessful. The most notable exceptions were the derivation of non-human primate ES cell lines followed shortly thereafter by their derivation of human ES cells. Despite the apparent common origin and the similar pluripotency of mouse and hu ...[more]

PMID: 17597762

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