Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human embryonic kidney cells overexpressing SMYD2 to identify which genes are regulated by SMYD2 through its histone lysine methylation activity

ABSTRACT: Identification of SMYD2 target genes - The objective of this aim is to identify which genes are regulated by SMYD2 through its histone lysine methylation activity. It is well established that post-translational modification of nucleosomal histones (H2A, H2B, H3 and H4), such as methylation, acetylation and phosphorylation are central to the proper control of gene expression

INSTRUMENT(S): G2565BA DNA microarray scanner [Agilent]

ORGANISM(S): Homo sapiens

SUBMITTER: Mohamed Abu-farha 

PROVIDER: E-MEXP-963 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase.

Abu-Farha Mohamed M   Lambert Jean-Philippe JP   Al-Madhoun Ashraf S AS   Elisma Fred F   Skerjanc Ilona S IS   Figeys Daniel D  

Molecular & cellular proteomics : MCP 20071207 3

Very little is known about SET- and MYND-containing protein 2 (SMYD2), a member of the SMYD protein family. However, the interest in better understanding the roles of SMYD2 has grown because of recent reports indicating that SMYD2 methylates p53 and histone H3. In this study, we present a combined proteomics and genomics study of SMYD2 designed to elucidate its molecular roles. We report the cytosolic and nuclear interactome of SMYD2 using a combination of immunoprecipitation coupled with high t  ...[more]

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