Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of lung from mice with doxycycline-induced TGFa-over-expression for 6 up to weeks, and up to 6 weeks of recovery to study TGFa-induced pulmonary fibrosis

ABSTRACT: Time series response to Doxycycline-induced TGFa-overexpression for 6 up to weeks, and up to 6 weeks of recovery.

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Mus musculus

SUBMITTER: Maureen Sartor 

PROVIDER: E-MEXP-966 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.

Hardie William D WD   Korfhagen Thomas R TR   Sartor Maureen A MA   Prestridge Adrienne A   Medvedovic Mario M   Le Cras Timothy D TD   Ikegami Machiko M   Wesselkamper Scott C SC   Davidson Cynthia C   Dietsch Maggie M   Nichols William W   Whitsett Jeffrey A JA   Leikauf George D GD  

American journal of respiratory cell and molecular biology 20070511 3

Expression of transforming growth factor alpha (TGF-alpha) in the respiratory epithelium of transgenic mice caused pulmonary fibrosis, cachexia, pulmonary hypertension, and altered lung function. To identify genes and molecular pathways mediating lung remodeling, mRNA microarray analysis was performed at multiple times after TGF-alpha expression and revealed changes consistent with a role for TGF-alpha in the regulation of extracellular matrix and vasculogenesis. Transcripts for extracellular ma  ...[more]

Similar Datasets

Transcriptomics Transcription profiling of C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD
2007-03-08 | E-MEXP-855 | biostudies-arrayexpress
Transcriptomics Transcription profiling of wild type and Ahr(-/-) mouse embryo fibroblast cells
2006-10-17 | E-MEXP-787 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse T cell sub-populations isolated from pulmonary tissue after mice were exposured to filtered air of acrolein for one week
2008-11-15 | E-MEXP-1354 | biostudies-arrayexpress
Transcriptomics Transcription profiling of dox-inducible, bitransgenic Ccsp-rtta x Teto-fgf7 mice lungs to 1 and 3 days of doxycycline treatment
2022-11-22 | E-MEXP-644 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse activin treated MEKK1 wild type and KO keratinocytes
2007-11-20 | E-MEXP-355 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse TGF-a induction in saccular phase and alveolar phase lung morphogenesis in mice
2022-11-21 | E-MEXP-698 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse fibroblasts expressing the 57Bl/6 Ah-receptor vs. Ahr-/- fibroblasts synchronized at G0/G1, S-phase, and in exponential growth
2007-08-05 | E-MEXP-996 | biostudies-arrayexpress
Transcriptomics Transcription profiling of lung from wild type and Mt1(-/-)Mt2(-/-) double knock-out mice after nickel aerosol exposure for 3, 8, 24, 48, and 72 hrs
2006-08-02 | E-MEXP-816 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse placenta to determine the relative effects of maternal and fetal genotype on the placental transcriptome at E18.5
2010-08-06 | E-MEXP-2479 | biostudies-arrayexpress
Transcriptomics Transcription profiling of Puga- tBHQ and arsenic treated GCLM-WT and KO mice
2005-12-08 | E-MEXP-371 | biostudies-arrayexpress