Transcription profiling of blood vessel endothelial cells from wild type and PPARb knock-out mice

ABSTRACT: To elucidate the mechanisms underlying the perturbation of tumor vascularization in Pparb–/– mice we performed matrigel plug assays23. Matrigel containing prostaglandin E2 (PGE2) and basic fibroblast growth factor (FGF-2) was injected subcutaneously into both wild-type and Pparb–/– mice where it formed semi-solid plugs. These plugs became rapidly invaded by AQP-1 positive cells. To analyze differences between Pparb+/+ and Pparb–/– samples we compare the gene expression profile of both samples by microarray analysis.

INSTRUMENT(S): ScanArray [PerkinElmer]

ORGANISM(S): Mus musculus

SUBMITTER: Dr. Wolfgang Meissner 

PROVIDER: E-MEXP-983 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress