Dataset Information
Transcription profiling of human heart tissue: hibernating versus normal myocardium
Ontology highlight
ABSTRACT:
Description: The aim of this project is to investigate the changes in global gene
expression in hibernating,(preserved wall thickness, impaired
contractility at rest, recruitable with low dose dobutamine
and 50% transmural hyperenhancement with gadolinium) and normal myocardium,
(preserved myocardial wall thickness, normal contractility, no significant improvement in functional recruitability with dobutamine and no cardiac fibrosis seen).
ORGANISM(S): Homo sapiens
SUBMITTER: Fowler Derek
PROVIDER: E-MIMR-27 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression profiling of human hibernating myocardium: increased expression of B-type natriuretic peptide and proenkephalin in hypocontractile vs normally-contracting regions of the heart.
European journal of heart failure 20081029 12
A greater understanding of the molecular basis of hibernating myocardium may assist in identifying those patients who would most benefit from revascularization. Paired heart biopsies were taken from hypocontractile and normally-contracting myocardium (identified by cardiovascular magnetic resonance) from 6 patients with chronic stable angina scheduled for bypass grafting. Gene expression profiles of hypocontractile and normally-contracting samples were compared using Affymetrix microarrays. The ...[more]
