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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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PAO1-Lon-ciprofloxacin

ABSTRACT: Microarray experiments were preformed comparing the effect of sub-inhibitory concentrations of ciprofloxacin on five independent cultures of PAO1 and the PAO1 Lon mutant

ORGANISM(S): Pseudomonas aeruginosa PAO1

SUBMITTER: Karsten Hokamp

PROVIDER: E-MTAB-1000 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Involvement of the lon protease in the SOS response triggered by ciprofloxacin in Pseudomonas aeruginosa PAO1.

Breidenstein Elena B M EB Bains Manjeet M Hancock Robert E W RE

Antimicrobial agents and chemotherapy 20120326 6

Pseudomonas aeruginosa PAO1 lon mutants have phenotypes of deficiencies in cell division, swarming, twitching, and biofilm formation as well as a phenotype of ciprofloxacin supersusceptibility. In this study, we demonstrated that a lon mutant was also supersensitive to the DNA-damaging agent UV light. To understand the influence of lon in causing these phenotypes, global gene expression was characterized by performing microarrays on the lon mutant and the PAO1 wild type grown in the presence of ...[more]

PMID: 22450976

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