Transcriptomics analysis of human of stage-specific atherosclerotic plaques: Signature mRNA-miRNA profile of disease severity

ABSTRACT: Detection of the altered expression of inflammation associated genes in patients’ blood can provide information regarding the stage of atherosclerotic plaque without undergoing invasive procedures. In the current study, the expression levels of miRNAs within the early stage and advanced stage atherosclerotic plaques was compared with left internal mammary tissue. Each of these tissues was obtained from 8 patients (males-5, females-3), aged 55-80 years, undergoing coronary artery bypass grafting surgery. Total RNA was isolated using Qiagen miRNeasy Mini Kit. The RNAs from the similar tissue types of 4 patients were pooled together to make one sample for one batch to be sequenced. Similarly, the RNAs from the same tissue type of remaining 4 patients were pooled together to be used as second

ORGANISM(S): Homo sapiens

SUBMITTER: Dipendra Kumar Mitra 

PROVIDER: E-MTAB-10051 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress