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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of human monocytic cell line (THP-1) treated with compound #42 (2D216), LPS, #42(2D216)/LPS, or vehicle controls

ABSTRACT: To explore the effects of compound #42 on RNA transcription of THP-1 cells, we performed RNA-seq analysis.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Tomoko Hayashi

PROVIDER: E-MTAB-10222 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity.

Saito Tetsuya T Shukla Nikunj M NM Sato-Kaneko Fumi F Sako Yukiya Y Hosoya Tadashi T Yao Shiyin S Lao Fitzgerald S FS Messer Karen K Pu Minya M Chan Michael M Chu Paul J PJ Cottam Howard B HB Hayashi Tomoko T Carson Dennis A DA Corr Maripat M

ACS chemical biology 20220105 1

There remains an unmet need for reliable fully synthetic adjuvants that increase lasting protective immune responses from vaccines. We previously reported a high-throughput screening for small molecules that extended nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) activation after a Toll-like receptor 4 (TLR4) ligand, lipopolysaccharide (LPS), stimulation using a human myeloid reporter cell line. We identified compounds with a conserved aminothiazole scaffold including <b> ...[more]

PMID: 34985883

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RNA-seq of human monocytic cell line (THP-1) treated with compound #42, LPS, #42/LPS, or vehicle controls

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Nitric oxide exposure induces production of Rpf-dependent differentially culturable mycobacteria

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