Repression of OSMR and FGFR1 by miR-1/133a prevents adult cardiomyocyte dedifferentiation and cell cycle entry in the adult heart

ABSTRACT: Deletion of the miR-1/133a clusters in adult cardiomyocytes results in upregulation of miRNA target genes FGFR1 and OSMR. Additional deletion of these miRNA target genes reveals a co-operative role of these receptors in the control of the cardiomyocyte differentiation state and in repression of cardiomyocyte cell cycle re-entry.

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Boettger 

PROVIDER: E-MTAB-10226 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress