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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional changes in MCF7 cells upon ISX treatment

ABSTRACT: MCF7 cells were treated with ISX, a novel GLI1 inducing HDAC-inhibitor

INSTRUMENT(S): Illumina HiSeq 1500

ORGANISM(S): Homo sapiens

SUBMITTER: Matthias Lauth

PROVIDER: E-MTAB-10248 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy.

Koeniger Anke A Brichkina Anna A Nee Iris I Dempwolff Lukas L Hupfer Anna A Galperin Ilya I Finkernagel Florian F Nist Andrea A Stiewe Thorsten T Adhikary Till T Diederich Wibke W Lauth Matthias M

Cancers 20210415 8

Although being rare in absolute numbers, neuroblastoma (NB) represents the most frequent solid tumor in infants and young children. Therapy options and prognosis are comparably good for NB patients except for the high risk stage 4 class. Particularly in adolescent patients with certain genetic alterations, 5-year survival rates can drop below 30%, necessitating the development of novel therapy approaches. The developmentally important Hedgehog (Hh) pathway is involved in neural crest differentia ...[more]

PMID: 33921042

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Project description:Transcriptional changes in MCF7 cells upon ISX treatment

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