Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of Arabidopsis SF3B145 mediated gene expression regulation

ABSTRACT: RNA-seq of Arabidopsis wild-type and atsf3b145 mutant seedling. The protein AtSF3B145 is involved in a subset of gene expression regulation.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Xiu-Ling Wang

PROVIDER: E-MTAB-10376 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Transcriptomic analysis identifies metabolic dysregulation in ARDS patients

Project description:To investigate the transcriptomic changes associated with ARDS progression, we performed RNA-seq on PBMCs from 6 healthy donors (Con), 7 ARDS patients

2026-06-30 | E-MTAB-17303 | biostudies-arrayexpress

RNA seq of HepG2 cells Ctrl vs LAP (CEBPB) OE

Project description:To gain insight into the gene signatures directly mediated by LAP (CEBPB) for cancer cell progression, we performed RNA-seq in LAP-HepG2 versus control cells.

2026-06-14 | E-MTAB-16207 | biostudies-arrayexpress

RNA-seq of Human Cortical Organoids Treated with Ciprofloxacin versus Untreated Controls

Project description:Human cortical organoids (hCOs) were employed to examine the developmental neurotoxic effects of ciprofloxacin (CPFX). Organoids were subjected to chronic exposure to low doses of CPFX for two weeks, while untreated organoids served as controls. Assessments included mitochondrial function, reactive oxygen species (ROS) production, and the expression of key neurodevelopmental regulators, including FOXG1, as well as genes associated with excitatory and inhibitory neuronal network formation. This study establishes a human-relevant model to investigate the molecular and functional consequences of CPFX exposure on cortical development.

2026-03-31 | E-MTAB-16792 | biostudies-arrayexpress

NEUROMESO

Project description:Exposure of mouse ESCs to a sequence of extrinsic signals, which recapitulates in vivo development, generates a bipotential neuromesodermal precursor (NMP) that can be directed to differentiate into either spinal cord or paraxial mesodermal tissue. To induce differentiation,mouse ES cells were plated on CellBINDSurface dishes (Corning) precoated with 0.1% gelatin (Sigma) at a density of 5x10^3 cells cm-2 in N2B27 medium. Cells were grown in N2B27 supplemented with 10ng/ml bFGF (R&D) for 3 days (D1-D3) and then were transferred into serum free media without bFGF (D3-D5). To induce ventral hindbrain identity NPCs (NH) 100nM RA (Sigma) and 500nM SAG (Calbiochem) was added from D3-D5. Spinal cord identity (NP) was induced by the addition of 5nM CHIR 99021 (Axon) from D2 to D3 followed by 100nM RA, 500nM SAG from D3-D5. To induce mesodermal differentiation the cells were treated with CHIR99021 from D2-D5.

2014-07-18 | E-MTAB-2268 | biostudies-arrayexpress

HepG2 WT vs CEBPB KO

Project description:WT HepG2 cells vs CEBPB knockout HepG2. CEBPB knockout HepG2 was generated from a single clone by CRISPR KO.

2026-06-14 | E-MTAB-16228 | biostudies-arrayexpress

ATAC-Seq analysis of MC38 colon carcinoma cells and MC38 Bap1-knockout cells

Project description:Genome-wide measurements of chromatin accessibility in MC38 colon carcinoma cells and MC38 Bap1-knockout cells.

2025-07-06 | E-MTAB-10593 | biostudies-arrayexpress

RNAseq (olfactory bulb) of temperature- and Franciscella challenged Atlantic cod (Gadhus morhua)

Project description:Atlantic cod (~70 g) were exposed to water temperatures of 12 and 17 degrees Celsius (flow-through system), then half the fish in each temperature group were infected with Francisella noatunensis (injection). Fish were sampled prior to temperature challenge, when water temp reached 17 degrees, and five weeks after infection. The left section of the olfactory organ was collected on RNAlater for RNA isolation and sequencing.

2023-08-30 | E-MTAB-12870 | biostudies-arrayexpress

The influence of the estrous cycle on sex differences in the rat adult medial prefrontal cortex transcriptome [RNA-Seq]

Project description:Hormonal fluctuations throughout the ovarian cycle contribute to femalesâ higher vulnerability to anxiety disorders when compared to males. Notably, such sex differences are controlled by regulation of genes in the medial prefrontal cortex (mPFC) including the transcription factor early growth response 1 (Egr1) in rats, which highlights a control of anxiety-like behaviors by sexually-biased gene expression. We therefore undertook a large-scale characterization of sex differences and their interaction with the estrous cycle in the adult mPFC transcriptome and report that proestrus and diestrus females (with high and low ovarian hormones levels, respectively) exhibited a partly-opposed sexually-biased transcriptome. Surprisingly, the extent of regulations within females vastly exceeded sex differences, and support a multi-level reorganization of synaptic function across the estrous cycle. Furthermore, genome-wide analysis of Egr1 binding highlighted its role in controlling the synapse-related genes varying within females, and the sex- and estrous cycle-dependent transcriptomic reorganization in the rat mPFC. mRNA profiling of 2-3 month-old males and females Sprague-Dawley rats in either Proestrus or Diestrus. A total of 11 samples were analyzed, corresponding to 4 males, 3 proestrus females, and 4 diestrus females.

2015-10-23 | E-GEOD-69765 | biostudies-arrayexpress

Deciphering the loss of fertility in ivermectin-treated Brugia malayi females in vitro: a transcriptomic approach [Study I]

Project description:In this study, we analyzed transcriptomic profiles from ivermectin-treated and -untreated B. malayi adult females using Next Generation RNA Sequencing technology at different concentrations (100 nM, 300 nM and 1 ÂµM) and time points (24, 48, 72 h, and 5 days). Our analysis revealed altered expression of multiple genes involved in meiosis, as well as oxidative phosphorylation which were significantly down-regulated as early as 24 hours post-exposure. RNA interference phenotypes of the orthologs of these down-regulated genes in C. elegans include âmaternal sterileâ, âembryonic lethalâ, âlarval arrestâ, âlarval lethalâ, âreduced brood sizeâ and âegg shape variableâ. These changes reflect and provide insight into the mechanisms involved in ivermectin-induced reduction in microfilaria output and impaired fertility, embryogenesis, and larval development. Transcriptomic changes over several different time points and concentrations.

2016-07-27 | E-GEOD-75339 | biostudies-arrayexpress

Deciphering the loss of fertility in ivermectin-treated Brugia malayi females in vitro: a transcriptomic approach [Study II]

2016-07-27 | E-GEOD-75340 | biostudies-arrayexpress