CGH analysis of an extramedullary muletiple myeloma PDX

ABSTRACT: A patient derived orthotopic xenograft (PDOX) was generated from a patient with an aggressive EMM to study in-depth genetic and epigenetic events and drug responses related to extramedullary disease. One of these studies was the evaluation of genetic imbalances by Affymetrix Cytoscan 750K array. The PDOX was derived from a fresh punch of an extramedullary cutaneous lesion that was orthotopically implanted in a NSG mouse. The PDOX mimicked histologic and phenotypic features of patient’s tumor. Cytogenetic studies revealed a hyperploid genome with multiple genetic poor-prognosis alterations. Copy number alterations were detected in all chromosomes.

ORGANISM(S): Homo sapiens

SUBMITTER: Lourdes Farre Vallve 

PROVIDER: E-MTAB-10630 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress