Activation of normal dermal fibroblasts by normal and cancer epithelial cells. Tissue cultures.

ABSTRACT: We model processes of wound healing and tumor growth, by studying the effects of normal and cancer epithelial cells on normal fibroblasts and their reciprocal effect on normal keratinocytes in vitro. We find strong parallels between the two processes and compare our observations with transcriptional analysis of 24 clinical samples of squamous cell carcinoma. This dataset contains the tissue culture samples, for the clinical samples, see E-MTAB-1065. Normal human fibroblasts (HF) were cocultured with either normal HK or transformed epithelial cells (HaCaT and FaDu) and their expression profile was compared to the expression profile of HF cultured alone.

ORGANISM(S): Homo sapiens

SUBMITTER: Michal Kolar 

PROVIDER: E-MTAB-1064 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress