Transcriptomic response in the heart and kidney to different types of antihypertensive drug administration

ABSTRACT: To unravel antihypertensive drug-induced gene expression changes that are potentially related to the amelioration of end-organ damages, we performed in vivo phenotypic evaluation and transcriptomic analysis on the heart and the kidney, with administration of antihypertensive drugs to two inbred strains of (i.e., hypertensive and normotensive) rats. We chose to use six antihypertensive classes: enalapril (angiotensin converting enzyme inhibitor), candesartan (angiotensin receptor blocker), hydrochlorothiazide (diuretics), amlodipine (calcium-channel blocker), carvedilol (vasodilating -blocker) and hydralazine. In the tested rat strains, four of six drugs, including two renin-angiotensin system (RAS) inhibitors, were effective for BP lowering, whereas the remaining two drugs were not. Besid

ORGANISM(S): Rattus norvegicus

SUBMITTER: Norihiro Kato 

PROVIDER: E-MTAB-10667 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress