ROBO3s: a novel ROBO3 shot isoform promoting breast cancer aggressiveness

ABSTRACT: We identified a novel uncharacterized short isoform of the Roundabout Guidance Receptor 3 (ROBO3) encoding for the C-terminal domain of the protein and lacking transmembrane region. We established an important role for the so-called ROBO3s isoform, mediating cancer stem cell properties by stimulating the Hippo-YAP signaling pathway, and thus driving the resistance of Basal-like breast cancer cells to cytotoxic drugs.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Florian Wegwitz 

PROVIDER: E-MTAB-10744 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress