Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization.
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ABSTRACT: 1) CRISPR-Cas9 screening of 3.5ng/mL rotenone-treated NPCs versus an ethanol control (treatments include 8 days and 23 days of treatment). 2) RNA-sequencing of NPCs treated with 10µg/mL antimycin A for 8 hours compared to an ethanol control 3) RNA-sequencing of whole C. elegans grown on empty-vector control or fed eps-8 RNAi
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Ryo Higuchi-Sanabria
PROVIDER: E-MTAB-10843 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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