Transcription profiling of yeast transcription factor knockout compendium

ABSTRACT: We reprocessed a recently published microarray compendium of 269 regulator knockouts that contains most known TFs and many epigenetic regulators for the yeast \italic{Saccharomyces cerevisiae} (Hu et al 2007). Using sensitive microarray analysis tools, we gained nearly 10 times more differentially expressed genes and recovered 90\% of previously described targets. We validated our analysis using Gene Ontology (GO), DNA-protein interactions, TF binding sites and protein-protein interactions. Our validation underlines the advantages of our sensitive analysis. The original data files for this submission can be found in E-MTAB-109.additional.zip

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Juri Reimand 

PROVIDER: E-MTAB-109 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress