MCL1 inhibitor induces apoptosis in Anaplastic Large Cell Lymphoma and in Primary Effusion Lymphoma

ABSTRACT: Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignanices and contributes to leukemogenesis by inhibiting the apoptotic machinery of the cells. BH3 mimetics provide an option for medication, with venetoclax as the first drug applied for chronic lymphocytic leukemia and for acute myeloid leukemia. To find additional hematologic entities with ectopic expression of BCL2 family members, we performed expression screening applying the LL-100 panel. Primary effusion lymphoma (PEL) and anaplastic large cell lymphoma (ALCL), 2/22 entities covered by this panel, stood out by high expression of MCL1 and low expression of BCL2. The MCL1 inhibitor AZD-5991 induced apoptosis in both malignancies suggesting that this BH3 mimetic might be efficient as drug for these d

INSTRUMENT(S): GeneChip® Pico Kit (Affymetrix), Affymetrix Clariom™ S (400 Format), Affymetrix GCS 3000

ORGANISM(S): Homo sapiens

SUBMITTER: Claudia Pommerenke 

PROVIDER: E-MTAB-10903 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress