Dataset Information
RNA-seq of Mus musculus subjected to cecal ligation or puncture to investigate inflammation-induced skeletal muscle atrophy
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Mus musculus
SUBMITTER: Daniele Yumi Sunaga-Franze
PROVIDER: E-MTAB-10960 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Journal of cachexia, sarcopenia and muscle 20211124 1
<h4>Background</h4>Sepsis and inflammation can cause intensive care unit-acquired weakness (ICUAW). Increased interleukin-6 (IL-6) plasma levels are a risk factor for ICUAW. IL-6 signalling involves the glycoprotein 130 (gp130) receptor and the JAK/STAT-pathway, but its role in sepsis-induced muscle wasting is uncertain. In a clinical observational study, we found that the IL-6 target gene, SOCS3, was increased in skeletal muscle of ICUAW patients indicative for JAK/STAT-pathway activation. We t ...[more]
