MiRNA-seq analysis of pre-seroconverted samples from fourteen children at risk of type 1 diabetes and their gender-, HLA-, and age-matched controls

ABSTRACT: We generated genome-wide whole-blood miRNA profiles for the fourteen multiple autoantibody-positive cases and their sex, age, and HLA-risk matched controls, using the miRNA-sequencing approach. Two samples just before the seroconversion from the fourteen case-control pairs were studied. Eight of the 10 cases progressed to clinical disease. A persistently autoantibody-negative control child was matched for each case, based on the date and place of birth, age, sex, and HLA-DQB1 genotype. In all, 56 unique blood samples were processed for genome-wide miRNA transcriptome analysis.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Riitta Lahesmaa 

PROVIDER: E-MTAB-10968 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress