SnoRNAs and miRNAs expression profiles underlying COVID-19 disease severity

ABSTRACT: The causative organism, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical manifestations in disease-ridden patients. Differences in the severity of COVID-19 ranges from asymptomatic infections and mild cases to the severe form, leading to acute respiratory distress syndrome (ARDS) and multiorgan failure with poor survival. MiRNAs can regulate various cellular processes, including proliferation, apoptosis, and differentiation, by binding to the 3′UTR of target mRNAs inducing their degradation, thus serving a fundamental role in post-transcriptional repression. Alterations of miRNA levels in the blood have been described in multiple inflammatory and infectious diseases, including SARS-related coronaviruses. We used microarrays to delineate the

ORGANISM(S): Home sapiens

SUBMITTER: Farhan Cyprian 

PROVIDER: E-MTAB-10970 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress