MicroRNA expression profiling of human pancreatic islets reveals microRNAs with altered expression due to glyceamic status

ABSTRACT: Global microRNA (miRNA) profiling was performed in 18 human islet donors using Exiqon’s LNA (locked nucleic acid)-based array platform. Donors were divided into three groups according to their HbA1c levels and type-2 diabetes diagnosis (normal glucose tolerance - NGT, impaired glucose tolerance - IGT, diagnosed with type-2 diabetes-T2D). To identify miRNAs with altered expression due to glyceamic status, donors were matched for age, gender and BMI and differential expression analysis was performed in 7 NGT vs 7 IGT/T2D donors using Significance Analysis of Microarrays (SAM) based on False Discovery Rate (FDR) statistics.

ORGANISM(S): Homo sapiens

SUBMITTER: Alexandros Karagiannopoulos 

PROVIDER: E-MTAB-11125 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress