Differential gene expression between borderline and adenocarcinoma in ovarian cancer

ABSTRACT: Ovarian tumors of the borderline subtype (BOL) are epithelial cancers tumors with very specific features. They rarely progress towards malignancy but their evolutionary profile, although remaining local, is distinct from that of benign cancers. At the cellular level, BOL are undistinguishable from malignant tumors (cytonuclear abnormalities, abnormal mitoses, anarchical proliferation), however they never invade the stroma, which makes them clearly distinct from carcinoma. BOL tumors are of good prognosis. Even when they relapse, these tumors remain local and are, most of the time, not invasive. Thus, comparing BOL with ovarian adenocarcinomas (ADK) is of major interest to decipher potential gene alterations underlying the process of invasion, a key step of oncogenesis. In this study, 20 B

ORGANISM(S): Homo sapiens

SUBMITTER: Philippe Dessen 

PROVIDER: E-MTAB-11177 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress