Constitutive abrB expression suppresses cell differentiation, restoring growth defect of a genome-reduced Bacillus subtilis strain and enhancing bioproduction

ABSTRACT: Genome-reduced strains have numerous beneficial traits such as improvement of bioproduction, better growth fitness and cell yield, since deleting large non-essential parts of the genomes enables removal of competing and unwanted metabolic pathways, however, can also result in undesirable phenotypes, such as growth defects. This was also the case for Bacillus subtilis MGB874 (Genome reduction strain, Morimoto et al., 2008), which has the excellent feature of increasing the productivity of cellulases and proteases, but also has the negative aspect of a reduced growth rate. B. subtilis is a soil bacterium that differentiates into various cells to form multicellular communities, but the related genes have to be strictly silenced by global transcription factor, AbrB, since expression of such ge

ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168

SUBMITTER: Taku Oshima 

PROVIDER: E-MTAB-11245 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress