Exosome RNA cargo in activated liver stellate cells

ABSTRACT: Previously we have described the role of liver stellate cell exosomes in triggering macrophage migration and immune activation, we wanted to study what cargo in this exosomes were responsible for such activation. We found a few interesting mRNAs and siRNAs involved in the immune response pathway and cytokine production. We have found that Ectodysplasin A, a hepatokine, has an important role in stimulating the macrophage response and to be highly expressed in liver cirrhosis.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Emilio Marrero 

PROVIDER: E-MTAB-11373 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress