HNF1A, H3K4me3 and H3K27ac ChIP-seq in control and Haster-deficient mouse livers

ABSTRACT: The HASTER promoter region is a cis-regulatory element that stabilizes the transcription of HNF1A, preventing silencing or overexpression. We have generated a mouse model where the promoter of Haster has been specifically deleted in liver (Haster loxP/loxP; AlbCre). In liver the prevailing consequence is upregulation of HNF1A. We performed HNF1A, H3K4me3 and H3K27ac ChIP-seq to assess the impact of HNF1A upregulation on the chromatin landscape of Haster KO liver.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Anthony Beucher 

PROVIDER: E-MTAB-11471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress