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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of wild type and L forms of Listeria monocytogenes

ABSTRACT: To understand gene expression of L forms

ORGANISM(S): Listeria monocytogenes

SUBMITTER: Carmen Buchrieser

PROVIDER: E-MTAB-116 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Listeria monocytogenes L-forms respond to cell wall deficiency by modifying gene expression and the mode of division.

Dell'Era Simone S Buchrieser Carmen C Couvé Elisabeth E Schnell Barbara B Briers Yves Y Schuppler Markus M Loessner Martin J MJ

Molecular microbiology 20090623 2

Cell wall-deficient bacteria referred to as L-forms have lost the ability to maintain or build a rigid peptidoglycan envelope. We have generated stable, non-reverting L-form variants of the Gram-positive pathogen Listeria monocytogenes, and studied the cellular and molecular changes associated with this transition. Stable L-form cells can occur as small protoplast-like vesicles and as multinucleated, large bodies. They have lost the thick, multilayered murein sacculus and are surrounded by a cyt ...[more]

PMID: 19555455

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