Hepatocyte-controlled availability of activated TGFb reprograms macrophage polarization affecting liver injury and regeneration

ABSTRACT: We describe a distinct macrophage population, whose presence in the liver during homoeostasis depends on recruitment signals mediated by the chemokine receptor CCR2. The identified polarization state of this population closely resembles that induced in co-culture experiments, where hepatocytes are reducing the availability of TGFb to macrophages. Accordingly, disruption of TGFb signal transduction in macrophages phenocopies the influence of hepatocytes on macrophage polarization.

INSTRUMENT(S): 10X Genomics Chromium Controller, NextSeq 550

ORGANISM(S): Mus musculus

SUBMITTER: Julio Saez-Rodriguez 

PROVIDER: E-MTAB-11727 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress