Transcriptomic profile of porcine corpus luteum after PPAR gamma ligands treatment

ABSTRACT: The corpus luteum plays a critical role in reproduction because it is the primary source of circulating progesterone. This study aimed to determine the in vitro effect of peroxisome proliferator-activated receptor gamma (PPARγ) ligands on the transcriptome genes expression in the porcine corpus luteum in the mid- and late-luteal phase of the estrous cycle using RNA-seq technology. The corpus luteum slices were incubated in vitro in the presence of PPARγ agonist – pioglitazone and antagonist—T0070907. We identified 40 differentially expressed genes after pioglitazone treatment and 40 after T0070907 treatment in the mid-luteal phase as well as 26 after pioglitazone and 29 after T0070907 treatment in late-luteal phase of the estrous cycle. In addition, we detected differences in genes express

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Sus scrofa

SUBMITTER: Karol Mierzejewski 

PROVIDER: E-MTAB-11964 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress