Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Study of the heterogeneity of mammalian pluripotent stem cell lines (monkey ESC nhsmv)

ABSTRACT: study of the heterogeneity of mammalian pluripotent stem cell lines

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Macaca mulatta

SUBMITTER: Gabriele Lubatti

PROVIDER: E-MTAB-11995 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Study of the heterogeneity of mammalian pluripotent stem cell lines (Pig ESCs and iPSCs)

Project description:study of the heterogeneity of mammalian pluripotent stem cell lines

2025-12-30 | E-MTAB-11996 | biostudies-arrayexpress

Study of the heterogeneity of mammalian pluripotent stem cell lines (Rabbit ESCs and iPSCs)

Project description:study of the heterogeneity of mammalian pluripotent stem cell lines

2025-12-30 | E-MTAB-11916 | biostudies-arrayexpress

Study of the heterogeneity of mammalian pluripotent stem cell lines (Cow ESCs)

Project description:study of the heterogeneity of mammalian pluripotent stem cell lines

2025-12-30 | E-MTAB-11994 | biostudies-arrayexpress

Study of the heterogeneity of mammalian pluripotent stem cell lines (Mouse ESCs and iPSCs)

Project description:study of the heterogeneity of mammalian pluripotent stem cell lines

2025-12-30 | E-MTAB-11835 | biostudies-arrayexpress

Single cell RNA seq of mouse embryonic stem cell line E14 with 2C::tbGFP reporter treated with Retinoic Acid for different time periods

Project description:Study of the emergence of the rare 2C like cell population upon Retinoic Acid treatment. Transcriptionally characterise the different cell populations emerging at different timepoints upon Retinoic Acid treatment and identify genes driving cell fate decisions.

2021-05-10 | E-MTAB-8869 | biostudies-arrayexpress

CIARA: a cluster independent algorithm for the identification of rare cell types from single cell RNA seq data

Project description:CIARA (Cluster Independent Algorithm for the identification of RAre cell types) is tested on mouse embryonic stem cell treated for 24h with Retinoic Acid.

2023-05-21 | E-MTAB-11610 | biostudies-arrayexpress

Single-cell sequencing of cerebral organoids with familial Alzheimer’s disease (AD) mutation in PSEN1 and non-demented control

Project description:We set up a 3D model based on iPSCs derived from patients with familial forms of Alzheimer’s disease (AD) and healthy non-demented control. We created cerebral organoids (COs), verified their ability to mimic AD in vitro, and used it to explore early events and the progression of AD pathogenesis. Our data reveal that despite similar expression of cell-type-specific genes during CO maturation in vitro, AD-iPSCs derived COs show limited tissue patterning and altered cellular development. These findings complement unique single-cell sequencing data of AD-iPSCs derived COs confirming this observation and uncovering that a sub-set of neurons in AD-iPSCs likely differentiates prematurely while at the same time retaining the expression of progenitor marker PAX6.

2022-07-01 | E-MTAB-11438 | biostudies-arrayexpress

scRNA-seq study of hippocampal microglia, perivascular macrophages and perivascular fibroblasts in pre-plaque APP-KI mice

Project description:Aim of this experiment was to characterize whether SPP1 released from the hippocampal perivascular space could imprint microglia transcriptional states. We performed scRNA-seq analysis on sorted CD140a+ perivascular fibroblast (PVF), CD45highCD11intCD206+ perivascular macrophage (PVM) and CD45intCD11intCX3CR1high microglial cell from dissected hippocampi of 6-month old wild type vs SPP1KO/KO vs AppNL-F mice vs AppNL-FxSpp1KO/KO mice. Cells were isolated from dissected hippocampi as previously described (Sala Frigerio et al.,2019).

2024-02-09 | E-MTAB-11918 | biostudies-arrayexpress

Single-cell transcriptomics of wild-type and cystic fibrosis (F508del/del) mouse uterus

Project description:Female cystic fibrosis (CF) patients are confronted with fertility deficiency, experiencing difficulties in getting pregnant. Previous findings using CF mouse models indicate that CF negatively impacts female fertility in mice as it does in humans. Underlying reasons remain elusive. In particular, it has only poorly been studied whether the endometrium, the inner lining of the womb and crucial tissue for embryo implantation, plays a role. Here, we applied single cell transcriptomics of wild-type (F508del <wt/wt>; WT) and CF (F508<del/del>) mouse uteri from the Cftr<tm1eur> mouse model, to get a detailed view on cellular and molecular/pathway differences in CF versus WT endometrium. Five uteri (WT: 3, CF: 2) were assessed in the estrus cycle of the estrous cycle, one CF uteri was sequenced during the diestrus cycle phase.

2025-10-31 | E-MTAB-14455 | biostudies-arrayexpress

Joint single-cell/single-nucleus RNA-seq on hearts from healthy or HFpEF mice

Project description:In this project we explore the cellular heterogeneity of a mouse model of heart failure with preserved ejection fraction (HFpEF) involving a two-hit model of feeding a high fat diet (HFD) along with L-NAME administration. Healthy adult male mice (C57BL/6J inbred) were fed either a normal chow diet or HFD/L-NAME for 10 weeks or 15 weeks before performing sequencing experiments. Both cardiomyocytes (CMs) and total interstitial population (TIP) were captured using a protocol to jointly capture and sequence single-nuclei (for cardiomyocytes) and single-cells (for TIP) using the 10x Genomics Chromium system.

2024-05-08 | E-MTAB-13362 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data